A growing number of human diseases have been found to be associated with aberrant DNA
methylation, including cancer. Mutations targeting genes encoding DNA methyltransferase …

Chronic occupational benzene exposure is associated with an increased risk of
hematological malignancies such as aplastic anemia and leukemia. The new biomarker and …

Melanoma is the most aggressive form of skin cancer resulting from genetic mutations in
melanocytes. Several factors have been considered to be involved in melanoma …

Polycyclic aromatic hydrocarbons (PAHs) exposure is associated with heart rate variability
(HRV) reduction, a widely used marker of cardiovascular autonomic dysfunction. The role of …

Background Epigenome-wide studies in hepatocellular carcinoma (HCC) have identified
numerous genes with aberrant DNA methylation. However, methods for triaging functional …

Breast cancer in very young women (≤ 35 years; BCVY) presents more aggressive and
complex biological features than their older counterparts (BCO). Our aim was to evaluate …

Genomic, chromosomal, and gene-specific changes in the DNA sequence underpin both
phenotypic variations in populations as well as disease associations, and the application of …

AIM: To examine the methylation levels of interleukin-1 receptor-associated kinase 3
(IRAK3) and GLOXD1 and their potential clinical applications in hepatocellular carcinoma …

Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) is a gammaherpesvirus
associated with several human malignancies. DNA methylation at CpG dinucleotides is an …

Increased methylation levels at cytosines proximal to guanines (CpG) in the promoter
regions of tumor suppressor genes have been reported to play an important role in the …