Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes
AA Tirpe, D Gulei, SM Ciortea, C Crivii… - International journal of …, 2019 - mdpi.com
Hypoxia represents a frequent player in a number of malignancies, contributing to the
development of the neoplastic disease. This review will discuss the means by which hypoxia …
development of the neoplastic disease. This review will discuss the means by which hypoxia …
Hypoxia-inducible factors: master regulators of cancer progression
L Schito, GL Semenza - Trends in cancer, 2016 - cell.com
Intratumoral hypoxia (reduced O 2 availability) is a common finding in human cancer and
leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the expression …
leads to increased activity of hypoxia-inducible factors (HIFs), which regulate the expression …
Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span
M Grunewald, S Kumar, H Sharife, E Volinsky… - Science, 2021 - science.org
INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …
other blood-borne substances and, in certain settings, also for the provision of endothelial …
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
C Yan, J Chen, C Wang, M Yuan, Y Kang, Z Wu… - Drug …, 2022 - Taylor & Francis
The refractory diabetic wound has remained a worldwide challenge as one of the major
health problems. The impaired angiogenesis phase during diabetic wound healing partly …
health problems. The impaired angiogenesis phase during diabetic wound healing partly …
Hypoxia-inducible factors: cancer progression and clinical translation
EE Wicks, GL Semenza - The Journal of clinical …, 2022 - Am Soc Clin Investig
Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
GL Semenza - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
Hypoxia occurs frequently in human cancers and induces adaptive changes in cell
metabolism that include a switch from oxidative phosphorylation to glycolysis, increased …
metabolism that include a switch from oxidative phosphorylation to glycolysis, increased …
[HTML][HTML] Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation
An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …
bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of …
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
GL Semenza - Trends in pharmacological sciences, 2012 - cell.com
Hypoxia-inducible factors (HIFs) mediate adaptive physiological responses to hypoxia. In
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …
human cancers that are accessible for O 2 electrode measurements, intratumoral hypoxia is …
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
HH Pulkkinen, M Kiema, JP Lappalainen… - Angiogenesis, 2021 - Springer
Abstract The BMP/TGFβ-Smad, Notch and VEGF signaling guides formation of endothelial
tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and …
tip and stalk cells. However, the crosstalk of bone morphogenetic proteins (BMPs) and …