Cardiovascular disease (CVD) is currently one of the prevalent causes of human death. Iron
is one of the essential trace elements in the human body and a vital component of living …

Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a
variety of cellular stress states. It is involved in regulating proteostasis and protecting cells …

Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key
regulator of lipid homeostasis. A few earlier genome-wide association studies (GWAS) …

Ferroptosis, distinct from apoptosis, necrosis, autophagy, and other types of cell death, is a
novel iron-dependent regulated cell death characterized by the accumulation of lipid …

Aging, an inevitable aspect of human existence, serves as one of the predominant risk
factors for vascular diseases. Delving into the mystery of vascular disease's …

Ferroptosis, a commonly observed type of programmed cell death caused by abnormal
metabolic and biochemical mechanisms, is frequently triggered by cellular stress. The …

Past research suggests that drugs that inhibit PCSK9 have potential as a novel therapy for
AAA to both limit aneurysm growth and reduce risk of cardiovascular events. A large …

Aims The lack of effective pharmacotherapies for aortic aneurysms (AA) is a persistent
clinical challenge. Lipid metabolism plays an essential role in AA. However, the impact of …

Objective The mitigation of abdominal aortic aneurysm (AAA) growth through
pharmaceutical intervention offers the potential to avert the perils associated with AAA …

Most patients with abdominal aortic aneurysm (AAA) are asymptomatic, being diagnosed
during an imaging evaluation for other symptoms. AAA rupture is an emergency, being one …