Platelets are chief effector cells in hemostasis. In addition, however, their specializations
include activities and intercellular interactions that make them key effectors in inflammation …

In the late 1960s, numerous investigators independently demonstrated that platelets are
capable of synthesizing proteins. Studies continued at a steady pace over the next 30 years …

To quantify how various molecular mechanisms are integrated to maintain platelet
homeostasis and allow responsiveness to adenosine diphosphate (ADP), we developed a …

Platelets are small anucleate cells generated from megakaryocytes in the bone marrow.
After being released into the circulation, platelets play key roles in the surveillance of …

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder of fibrinogen-
mediated platelet aggregation due to a quantitative or qualitative deficit of the αIIbβ3 integrin …

This chapter presents an overview and introduction to blood coagulation models. The
historical exposure of the development of classical coagulation modeling theories is …

Since the original observations by Bizzozero and Osler, we have seen tremendous
advances in the understanding of platelets far beyond haemostasis and the restoration of …

Intravital microscopy is a powerful method that has been widely used to directly visualize
molecular and cellular events in live animals. 1-3 The first well-documented report of …

Objective I investigated whether the platelet distribution width/platelet count (PDW/PC) ratio,
which is an inexpensive and simple test performed for almost all patients, is applicable in the …

This chapter is devoted to the description and modeling of the process of blood coagulation
which is crucial for life and is the result of an intricate sequence of chemical reactions …