Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …

Wound healing requires cooperation between different cell types, among which
macrophages play a central role. In particular, inflammatory macrophages are engaged in …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …

Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …

Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain.
Using a knockin mouse line in which a Td-tomato reporter is incorporated into the …