Human bone marrow permanently harbors high numbers of neutrophils, and a tumor-
supportive bias of these cells could significantly impact bone marrow-confined …

Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …

The complement system is a part of the immune system and consists of multiple complement
components with biological functions such as defense against pathogens and …

Abstract Background Synovial fibroblasts (SFs) are specialized cells of the synovium that
provide nutrients and lubricants for the proper function of diarthrodial joints. Recent …

C3 is the central effector molecule of the complement system, mediating its multiple
functions through different binding sites and their corresponding receptors. We will introduce …

The complement component C3 is a fundamental plasma protein for host defense, produced
largely by the liver. However, recent work has demonstrated the critical importance of tissue …

Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

The term fibroblast has been used generally to describe spindle-shaped stromal cells of
mesenchymal origin that produce extracellular matrix, establish tissue structure, and form …

Fibroblast-like synoviocytes or synovial fibroblasts (FLS) are important cellular components
of the inner layer of the joint capsule, referred to as the synovial membrane. They can be …