Defining the underlying defect in insulin action in type 2 diabetes
Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …
the past 50 years, elucidation of the insulin signalling network has provided important …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: a nested case-control …
JC Chambers, M Loh, B Lehne, A Drong… - The lancet Diabetes & …, 2015 - thelancet.com
Summary Background Indian Asians, who make up a quarter of the world's population, are
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
at high risk of developing type 2 diabetes. We investigated whether DNA methylation is …
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
Epigenetics and human obesity
Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …
increasing number of studies investigating the role of the epigenome in obesity. There is …
Inflammageing and metaflammation: the yin and yang of type 2 diabetes
F Prattichizzo, V De Nigris, R Spiga, E Mancuso… - Ageing research …, 2018 - Elsevier
Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation,
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
E Nilsson, PA Jansson, A Perfilyev, P Volkov… - Diabetes, 2014 - Am Diabetes Assoc
Genetics, epigenetics, and environment may together affect the susceptibility for type 2
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …
diabetes (T2D). Our aim was to dissect molecular mechanisms underlying T2D using …