Age-associated changes to the mammalian DNA methylome are well documented and
thought to promote diseases of aging, such as cancer. Recent studies have identified …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …

Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood
cells with one or more somatic mutations. Individuals with CH are at greater risk for …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …

Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which
contribute to it as a recalcitrant malignancy. To understand the molecular mechanisms …

Upon stimulation by extrinsic stimuli, stem cells initiate a programme that enables
differentiation or self-renewal. Disruption of the stem state exit has catastrophic …

The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …

DNA methylation patterns are disrupted in various malignancies, suggesting a role in the
development of cancer, but genetic aberrations directly linking the DNA methylation …