The remarkable fidelity of DNA replication and the predictable transmission of Mendelian
traits sometimes appear to attenuate the fluidity of the genome. In humans, abundant …

Transgenic fish, owing to a number of advantages which they offer over other species, are
proving to be valuable model systems for the study of gene regulation and developmental …

Background Although the transient nature of transgene expression using first‐generation
adenovirus (Ad) vectors is well known, the exact mechanisms responsible for this …

Homologous recombination between dispersed DNA repeats creates chromosomal
rearrangements that are deleterious to the genome. The methylation associated with DNA …

The fragile-X syndrome of mental retardation is associated with an expansion in the number
of CGG repeats present in the FMR1 gene. The repeat region is within sequences …

Transgenic animals have been used for years to study gene function, produce important
proteins, and generate models for the study of human diseases. However, inheritance and …

Background & Aims: JC virus (JCV) is a polyomavirus that ubiquitously infects humans and
has been implicated in various human cancers. JCV encodes a “transforming” gene, T …

ABSTRACT DNA methylation and histone modifications are vital in maintaining genomic
stability and modulating cellular functions in mammalian cells. These two epigenetic …

Maternal nutrition during gestation has important effects on offspring gene expression
mediated by DNA methylation. In order to evaluate the effect of restricted and excess protein …

During the past 20 years, transgenesis has become a popular technique and a crucial tool
for molecular geneticists and biologists. Transgene expression is now better-controlled and …