The tools for virulence of Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
Overview of selected virulence attributes in Aspergillus fumigatus, Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, and Exophiala dermatitidis
H Boral, B Metin, A Döğen, S Seyedmousavi… - Fungal Genetics and …, 2018 - Elsevier
The incidence of fungal diseases has been increasing since 1980, and is associated with
excessive morbidity and mortality, particularly among immunosuppressed patients. Of the …
excessive morbidity and mortality, particularly among immunosuppressed patients. Of the …
Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans
J Rizzo, A Trottier, F Moyrand, JY Coppée, C Maufrais… - MBio, 2023 - Am Soc Microbiol
Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved
by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a …
by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a …
Synergy and antagonism between iron chelators and antifungal drugs in Cryptococcus
Fungal infections remain very difficult to treat, and developing new antifungal drugs is
difficult and expensive. Recent approaches therefore seek to augment existing antifungals …
difficult and expensive. Recent approaches therefore seek to augment existing antifungals …
Iron pathways and iron chelation approaches in viral, microbial, and fungal infections
R Chhabra, A Saha, A Chamani, N Schneider, R Shah… - Pharmaceuticals, 2020 - mdpi.com
Iron is an essential element required to support the health of organisms. This element is
critical for regulating the activities of cellular enzymes including those involved in cellular …
critical for regulating the activities of cellular enzymes including those involved in cellular …
Iron assimilation during emerging infections caused by opportunistic fungi with emphasis on Mucorales and the development of antifungal resistance
FA Stanford, K Voigt - Genes, 2020 - mdpi.com
Iron is a key transition metal required by most microorganisms and is prominently utilised in
the transfer of electrons during metabolic reactions. The acquisition of iron is essential and …
the transfer of electrons during metabolic reactions. The acquisition of iron is essential and …
UPC2 Is Universally Essential for Azole Antifungal Resistance in Candida albicans
In Candida albicans, the transcription factor Upc2 is central to the regulation of ergosterol
biosynthesis. UPC2-activating mutations contribute to azole resistance, whereas disruption …
biosynthesis. UPC2-activating mutations contribute to azole resistance, whereas disruption …
XCluSim: a visual analytics tool for interactively comparing multiple clustering results of bioinformatics data
Background Though cluster analysis has become a routine analytic task for bioinformatics
research, it is still arduous for researchers to assess the quality of a clustering result. To …
research, it is still arduous for researchers to assess the quality of a clustering result. To …
Fe‐S Clusters Emerging as Targets of Therapeutic Drugs
L Vernis, N El Banna, D Baïlle, E Hatem… - Oxidative Medicine …, 2017 - Wiley Online Library
Fe‐S centers exhibit strong electronic plasticity, which is of importance for insuring fine
redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly …
redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly …
Genomic Multiplication and Drug Efflux Influence Ketoconazole Resistance in Malassezia restricta
Malassezia restricta is an opportunistic fungal pathogen on human skin; it is associated with
various skin diseases, including seborrheic dermatitis and dandruff, which are usually …
various skin diseases, including seborrheic dermatitis and dandruff, which are usually …