Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

The incidence of fungal diseases has been increasing since 1980, and is associated with
excessive morbidity and mortality, particularly among immunosuppressed patients. Of the …

Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved
by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a …

Fungal infections remain very difficult to treat, and developing new antifungal drugs is
difficult and expensive. Recent approaches therefore seek to augment existing antifungals …

Iron is an essential element required to support the health of organisms. This element is
critical for regulating the activities of cellular enzymes including those involved in cellular …

Iron is a key transition metal required by most microorganisms and is prominently utilised in
the transfer of electrons during metabolic reactions. The acquisition of iron is essential and …

In Candida albicans, the transcription factor Upc2 is central to the regulation of ergosterol
biosynthesis. UPC2-activating mutations contribute to azole resistance, whereas disruption …

Background Though cluster analysis has become a routine analytic task for bioinformatics
research, it is still arduous for researchers to assess the quality of a clustering result. To …

Fe‐S centers exhibit strong electronic plasticity, which is of importance for insuring fine
redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly …

Malassezia restricta is an opportunistic fungal pathogen on human skin; it is associated with
various skin diseases, including seborrheic dermatitis and dandruff, which are usually …