Enzymatically oxidized lipids are a specific group of biomolecules that function as key
signaling mediators and hormones, regulating various cellular and physiological processes …

Cytochromes P450s (CYPs) constitute a superfamily of enzymes that catalyze the
metabolism of drugs and other substances. Endogenous substrates of CYPs include …

Abstract DrugBank (www. drugbank. ca) is a web-enabled database containing
comprehensive molecular information about drugs, their mechanisms, their interactions and …

Genetic polymorphisms in cytochrome P450 (CYP) genes can result in altered metabolic
activity toward a plethora of clinically important medications. Thus, single nucleotide variants …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than
2,000 mutations have been described, and certain single nucleotide polymorphisms (SNPs) …

CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of
small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these …

Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …

Clinical genetic testing has grown substantially over the past 30 years as the causative
mutations for Mendelian diseases have been identified, particularly aided in part by the …

Oral administration is the most commonly used route for drug treatment. Intestinal
cytochrome P450 (CYP)-mediated metabolism can eliminate a large proportion of some …