Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Managing traumatic brain injury (TBI) patients with a cerebral perfusion pressure (CPP) near
to the cerebral autoregulation (CA)-guided “optimal” CPP (CPPopt) value is associated with …

Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Cerebral autoregulation (CA) refers to the control of cerebral tissue blood flow (CBF) in
response to changes in perfusion pressure. Due to the challenges of measuring intracranial …

Abstract In 1959, Niels Lassen illustrated the cerebral autoregulation curve in the classic
review article entitled Cerebral Blood Flow and Oxygen Consumption in Man. This concept …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Posterior Reversible Encephalopathy Syndrome | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …