The prevalence of maternal obesity has risen dramatically in recent years, with
approximately one in five pregnant women in the UK now classed as obese (body mass …

Accumulating evidence suggests that both the intrauterine environment and growth during
early life can influence the development of chronic noncommunicable diseases, such as …

BACKGROUND The sperm chromatin of fertile men retains a small number of nucleosomes
that are enriched at developmental gene promoters and imprinted gene loci. This unique …

Mounting evidence from both animal and human studies suggests that the epigenome is in
constant drift over the life course in response to stochastic and environmental factors. In …

Background There is evidence that altered DNA methylation is an important epigenetic
mechanism in prenatal programming and that developmental periods are sensitive to …

Preeclampsia and intrauterine growth restriction (IUGR) are two of the most common
adverse pregnancy outcomes, but their underlying causes are mostly unknown. Although …

Throughout in utero development, the placenta plays a key role in controlling growth and
development. The placenta acts not only as a gatekeeper of nutrient and waste exchange …

Studies have shown that lncRNA DANCR is down-regulated in placental tissues of patients
with preeclampsia (PE). The aim of this study was to explore the effect of lncRNA DANCR on …

Preeclampsia is a pregnancy-specific syndrome mainly characterized by hypertensive
disorder and proteinuria after gestational weeks 20. So far the etiology of preeclampsia …

Preeclampsia is a common pregnancy complication which can have adverse impact on both
mother and baby. In addition to the short term effects, a large body of epidemiological …