Replication of the two template strands at eukaryotic cell DNA replication forks is a highly
coordinated process that ensures accurate and efficient genome duplication. Biochemical …

Abstract DNA Polymerase Epsilon (Pol ε) is one of three DNA Polymerases (along with Pol δ
and Pol α) required for nuclear DNA replication in eukaryotes. Pol ε is comprised of four …

During human nucleotide excision repair, damage is recognized, two incisions are made
flanking a DNA lesion, and residues are replaced by repair synthesis. A set of proteins …

Although three human genes encoding DNA ligases have been isolated, the molecular
mechanisms by which these gene products specifically participate in different DNA …

The two DNA strands of the nuclear genome are replicated asymmetrically using three DNA
polymerases, α, δ, and ε. Current evidence suggests that DNA polymerase ε (Pol ε) is the …

Bulk replicative DNA synthesis in eukaryotes is highly accurate and efficient, primarily
because of two DNA polymerases (Pols): Pols δ and ε. The high fidelity of these enzymes is …

The identity of DNA replication proteins and cell cycle regulatory proteins which can be
found in complexes involving PCNA were investigated by the use of PCNA immobilized on …

Nonhomologous DNA end joining (NHEJ) is considered the major pathway of double‐strand
break (DSB) repair in vertebrate cells. Various studies indicated the existence of at least two …

Publisher Summary DNA polymerase epsilon (Pol epsilon) is a large, multi-subunit
polymerase that is conserved throughout all eukaryotes. In addition to its role as one of the …

Maintenance of the information embedded in the genomic DNA sequence is essential for
life. DNA polymerases play pivotal roles in the complex processes that maintain genetic …