Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

Background Friend leukemia virus integration 1 (FLI1), an ETS transcription factor family
member, acts as an oncogenic driver in hematological malignancies and promotes tumor …

Modification of DNA bases plays vital roles in the epigenetic control of gene expression in
both animals and plants. Though much attention is given to the conventional epigenetic …

DNA methylation is one of the best characterized epigenetic modifications. In mammals it is
involved in various biological processes including the silencing of transposable elements …

Methylation of cytosines in the mammalian genome represents a key epigenetic modification
and is dynamically regulated during development. Compelling evidence now suggests that …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

DNA hypermethylation at the promoter of tumour-suppressor genes is tightly correlated with
their transcriptional repression and recognized as the hallmark of majority of cancers …

Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the
formation and measurement of oxidatively generated damage in cellular DNA in order to …