DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation
J Cadet, JR Wagner - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Emphasis has been placed in this article dedicated to DNA damage on recent aspects of the
formation and measurement of oxidatively generated damage in cellular DNA in order to …
formation and measurement of oxidatively generated damage in cellular DNA in order to …
A double take on bivalent promoters
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …
the control of gene expression, supervising cell fate decisions and differentiation. Many …
Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications
Gliomas are a heterogeneous group of brain tumors with distinct biological and clinical
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …
properties. Despite advances in surgical techniques and clinical regimens, treatment of high …
[HTML][HTML] Epigenomic analysis of multilineage differentiation of human embryonic stem cells
Epigenetic mechanisms have been proposed to play crucial roles in mammalian
development, but their precise functions are only partially understood. To investigate …
development, but their precise functions are only partially understood. To investigate …
[HTML][HTML] Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
DNA methylation at the 5 position of cytosine (5-mC) is a key epigenetic mark that is critical
for various biological and pathological processes. 5-mC can be converted to 5 …
for various biological and pathological processes. 5-mC can be converted to 5 …
[HTML][HTML] Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
A Breiling, F Lyko - Epigenetics & chromatin, 2015 - Springer
The chemical modification of DNA bases plays a key role in epigenetic gene regulation.
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …
While much attention has been focused on the classical epigenetic mark, 5-methylcytosine …
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
DNA hydroxymethylation and its mediated DNA demethylation are critical for multiple
cellular processes, for example, nuclear reprogramming, embryonic development, and many …
cellular processes, for example, nuclear reprogramming, embryonic development, and many …
Single-cell methylome landscapes of mouse embryonic stem cells and early embryos analyzed using reduced representation bisulfite sequencing
DNA methylation is crucial for a wide variety of biological processes, yet no technique
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
suitable for the methylome analysis of DNA methylation at single-cell resolution is available …
DNA methylation dynamics in health and disease
Y Bergman, H Cedar - Nature structural & molecular biology, 2013 - nature.com
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-
established at the time of implantation. In this Review, dynamics of DNA methylation during …
established at the time of implantation. In this Review, dynamics of DNA methylation during …
Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia
BJ Wouters, R Delwel - Blood, The Journal of the American …, 2016 - ashpublications.org
Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …
a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent …