[HTML][HTML] Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation
Summary TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in
various biological processes. Mutations of TET2 are frequently observed in myeloid …
various biological processes. Mutations of TET2 are frequently observed in myeloid …
Analysing and interpreting DNA methylation data
C Bock - Nature Reviews Genetics, 2012 - nature.com
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …
of biological processes and diseases. The technology is now available for studying DNA …
Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
W Li, F Teng, T Li, Q Zhou - Nature biotechnology, 2013 - nature.com
(Supplementary Figs. 1–4). Previous studies suggested that CRISPR-Cas systems may
tolerate sequence mismatches distal from the protospacer adjacent motif (PAM) at the 5о …
tolerate sequence mismatches distal from the protospacer adjacent motif (PAM) at the 5о …
Genome-wide analysis reveals TET-and TDG-dependent 5-methylcytosine oxidation dynamics
TET dioxygenases successively oxidize 5-methylcytosine (5mC) in mammalian genomes to
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) …
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) …
Epigenetic determinants of cancer
Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …
Pain vulnerability: a neurobiological perspective
There are many known risk factors for chronic pain conditions, yet the biological
underpinnings that link these factors to abnormal processing of painful signals are only just …
underpinnings that link these factors to abnormal processing of painful signals are only just …
Epigenetic mechanisms of drug addiction
EJ Nestler - Neuropharmacology, 2014 - Elsevier
Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …
Dynamic integration of splicing within gene regulatory pathways
U Braunschweig, S Gueroussov, AM Plocik… - Cell, 2013 - cell.com
Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …
[HTML][HTML] Gene methylation in gastric cancer
Y Qu, S Dang, P Hou - Clinica chimica acta, 2013 - Elsevier
Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …