Summary TET proteins oxidize 5-methylcytosine (5mC) on DNA and play important roles in
various biological processes. Mutations of TET2 are frequently observed in myeloid …

DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …

(Supplementary Figs. 1–4). Previous studies suggested that CRISPR-Cas systems may
tolerate sequence mismatches distal from the protospacer adjacent motif (PAM) at the 5о …

TET dioxygenases successively oxidize 5-methylcytosine (5mC) in mammalian genomes to
5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) …

Epigenetic changes are present in all human cancers and are now known to cooperate with
genetic alterations to drive the cancer phenotype. These changes involve DNA methylation …

There are many known risk factors for chronic pain conditions, yet the biological
underpinnings that link these factors to abnormal processing of painful signals are only just …

Drug addiction involves potentially life-long behavioral abnormalities that are caused in
vulnerable individuals by repeated exposure to a drug of abuse. The persistence of these …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …