Cytosine methylation is an epigenetically propagated DNA modification that can modify how
the DNA molecule is recognized and expressed. DNA methylation undergoes extensive …

Simple Summary DNA methylation is involved in biological processes including
neurogenesis, aging, and the pathogenesis of brain disorders by the regulation of gene …

Abstract Background Ten-Eleven Translocation (TETs) proteins mediate the oxidation of 5-
methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Tet1 is expressed at high levels …

Abstract The formation of 5-hydroxymethylcytosine (5hmC), a key intermediate of DNA
demethylation, is driven by the ten eleven translocation (TET) family of proteins that oxidize …

Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …

Little is known about how patterns of DNA methylation change during mammalian
spermatogenesis. 5hmC has been recognized as a stable intermediate of DNA …

Ten-eleven translocation (TET) enzymes mediate the conversion of 5-methylcytosine (5mC)
to 5-hydroxymethylcytosine (5hmC), which is enriched in brain, and its ultimate DNA …

DNA methylation is one of the critical epigenetic modifications regulating various cellular
processes such as differentiation or proliferation, and its dysregulation leads to disordered …

During the last decade, high-throughput sequencing efforts in the fields of transcriptomics
and epigenomics have shed light on the noncoding part of the transcriptome and its …

Endogenous and exogenous factors constantly challenge cellular DNA, generating cytotoxic
and/or mutagenic DNA adducts. As a result, organisms have evolved different mechanisms …