Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …
second most prevalent aortic disease following atherosclerosis, representing the ninth …
[HTML][HTML] The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
The Year of the Rat: The Rat Genome Database at 20: a multi-species knowledgebase and analysis platform
JR Smith, GT Hayman, SJ Wang… - Nucleic acids …, 2020 - academic.oup.com
Formed in late 1999, the Rat Genome Database (RGD, https://rgd. mcw. edu) will be 20 in
2020, the Year of the Rat. Because the laboratory rat, Rattus norvegicus, has been used as …
2020, the Year of the Rat. Because the laboratory rat, Rattus norvegicus, has been used as …
Lack of an effective drug therapy for abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …
[HTML][HTML] Smoking and the pathophysiology of peripheral artery disease
W Wang, T Zhao, K Geng, G Yuan, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Smoking is one of the most important preventable factors causing peripheral artery disease
(PAD). The purpose of this review is to comprehensively analyze and summarize the …
(PAD). The purpose of this review is to comprehensively analyze and summarize the …
[HTML][HTML] Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
[HTML][HTML] Microfibrillar-associated protein 4 in health and disease
R Kanaan, M Medlej-Hashim, R Jounblat, B Pilecki… - Matrix Biology, 2022 - Elsevier
Abstract Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix protein
belonging to the fibrinogen-related domain family. It has been localized to elastic fiber-rich …
belonging to the fibrinogen-related domain family. It has been localized to elastic fiber-rich …
Mouse models for abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …
Twenty years of studying AngII (angiotensin II)-induced abdominal aortic pathologies in mice: continuing questions and challenges to provide insight into the human …
AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into
human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal …
human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal …
[HTML][HTML] Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis
Y Ishida, Y Kuninaka, M Nosaka, A Kimura… - Nature …, 2020 - nature.com
Inflammatory mediators such as cytokines and chemokines are crucially involved in the
development of abdominal aortic aneurysm (AAA). Here we report that CaCl2 application …
development of abdominal aortic aneurysm (AAA). Here we report that CaCl2 application …