Postbiotics are functional bioactive compounds, generated in a matrix during fermentation,
which may be used to promote health. The term postbiotics can be regarded as an umbrella …

A compelling set of links between the composition of the gut microbiota, the host diet, and
host physiology has emerged. Do these links reflect cause-and-effect relationships, and …

We describe the anaerobic conversion of inositol stereoisomers to propionate and acetate
by the abundant intestinal genus Anaerostipes. A inositol pathway was elucidated by …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Histone dacetylases (HDACs) are a group of enzymes that remove acetyl groups from
histones and regulate expression of tumor suppressor genes. They are implicated in many …

Immunometabolism has emerged as a key focus for immunologists, with metabolic change
in immune cells becoming as important a determinant for specific immune effector …

Background Treatment with the α-glucosidase inhibitor acarbose increases median lifespan
by approximately 20% in male mice and 5% in females. This longevity extension differs from …

The cell cycle is controlled by precise mechanisms to prevent malignancies such as cancer,
and the cell needs these tight and advanced controls. Cyclin dependent kinase inhibitor p27 …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …

The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …