The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

Exosome-derived circCCAR1 promotes CD8+ T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Z Hu, G Chen, Y Zhao, H Gao, L Li, Y Yin, J Jiang… - Molecular cancer, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) can be encapsulated into exosomes to
participate in intercellular communication, affecting the malignant progression of a variety of …

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

J Wang, F Wang, J Ke, Z Li, C Xu, Q Yang… - Science Translational …, 2022 - science.org
The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …

m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer

H Huang, H Weng, J Chen - Cancer cell, 2020 - cell.com
N 6-Methyladenosine (m 6 A) RNA modification has emerged in recent years as a new layer
of regulatory mechanism controlling gene expression in eukaryotes. As a reversible …

The potential role of RNA N6-methyladenosine in Cancer progression

T Wang, S Kong, M Tao, S Ju - Molecular cancer, 2020 - Springer
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and
conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA) …

Insights into N6-methyladenosine and programmed cell death in cancer

L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …

Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma

L Liu, M Gu, J Ma, Y Wang, M Li, H Wang, X Yin, X Li - Molecular cancer, 2022 - Springer
Background Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA
methylation participate in the pathogenesis and metastasis of multiple malignancies …