Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Although obesity, reduced physical activity, and aging increase susceptibility to type 2
diabetes, many people exposed to these risk factors do not develop the disease. Recent …

Eukaryotic chromatin is kept flexible and dynamic to respond to environmental, metabolic,
and developmental cues through the action of a family of so-called “nucleosome …

There is a growing body of evidence that links epigenetic modifications to type 2 diabetes.
Researchers have more recently investigated effects of commonly used medications …

DNA methylation is a major epigenetic modification in the genomes of higher eukaryotes. In
vertebrates, DNA methylation occurs predominantly on the CpG dinucleotide, and …

DNA methylation is an epigenetic mechanism that play an important role in gene regulation
in response to environmental conditions. The understanding of DNA methylation at the …

This review presents the different human DNA methyltransferases (DNMTs), their biological
roles, their mechanisms of action and their role in cancer. The description of assays for …

DNA methylation plays an important role in gene regulation in animals. However, the
evolution and function of DNA methylation has only recently emerged as the subject of …

Environments experienced by organisms during early development shape the character and
timing of developmental processes, leading to different probabilities of survival in the …

One of the most significant problems in industrial bioprocessing of recombinant proteins
using engineered mammalian cells is the phenomenon of cell line instability, where a …