Ferroptosis is a new iron-dependent form of programmed cell death characterized by iron
accumulation and lipid peroxidation. In recent years, ferroptosis has garnered enormous …

Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Ferroptosis is a non‐apoptotic programmed cell death caused by the accumulation of lipid
peroxide. System Xc‐/glutathione peroxidase 4 (GPX4) axis and iron axis are two main …

Immunotherapy has been widely used in clinical practice, but the therapeutic effects on
many cancers are still poor, possibly because some patients are not sensitive to …

A potential reason for the failure of tumor therapies is treatment resistance. Resistance to
chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic …

As an indispensable micronutrient, copper (Cu) plays an important role in promoting
metabolism and maintaining various basic biological functions. Copper homeostasis in the …

Highlights•Matrine (MT) is potentially toxic to the liver.•The hepatotoxic effects of MT involve
disruption of iron homeostasis.•The hepatotoxicity of MT involves Nrf2/GPX4 system …

Ferroptosis is a form of programmed cell death and plays an important role in many
diseases. Dihydroorotate dehydrogenase (DHODH) and glutathione peroxidase 4 (GPX4) …

The accumulation of lethal reactive oxygen species (ROS) and lipid peroxidation (LPO) is
the hallmark of ferroptosis therapy. However, a single ferroptosis process has difficulty …

The ability of cancer stem cells (CSCs) to self-renew, differentiate, and generate new tumors
is a significant contributor to drug resistance, relapse, and metastasis. Therefore, the …