In mammals, genomic imprinting results from different sets of epigenetic marks that
distinguish the parental origins of loci in the progeny. Epigenetic reprogramming of genomic …

Classical genomic imprints are regulated by parent-specific DNA methylation levels
inherited from the gametes in mammals. Imprints control gene expression in a parent-of …

Primary oocyte determination occurs in many organisms within a germ line cyst, a
multicellular structure composed of interconnected germ cells. However, the structure of the …

Germ cells are the origin of new individuals. Hence, specifying germ cell identity is crucial for
reproduction. The recent establishment of in vitro culture systems for generating oocytes …

Innovations in ultrasensitive and single-cell measurements enable us to study layers of
genome regulation in view of cellular and regulatory heterogeneity. Genome-scale mapping …

哺乳动物早期胚胎发育过程中, 受精卵经历了一系列表观遗传重编程事件,
去除了雌雄原核的表观遗传记忆, 从而建立了胚胎的全能性. 然而, 这些重编程事件的进行必须 …

Abstract Cleavage Under Target & Release Using Nuclease (CUT&RUN) enables the
detection of DNA regions that are bound by a protein of interest. This method is suitable for …

The very first days of mammalian embryonic development are accompanied by epigenetic
reprogramming and extensive changes in nuclear organization. In particular, genomic …

Polycomb-group proteins assemble into two primary complexes—Polycomb repressive
complex (PRC) 1 and 2—that safeguard cell fate by repressing gene transcription. Two new …

Epigenetic modifications play a pivotal role in gene expression regulation and thus actively
participate in multiple developmental processes. Among them, DNA methylation and histone …