Insights on aortic aneurysm and dissection: Role of the extracellular environment in vascular homeostasis

Y Wang, P Gao, F Li, J Du - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
Aortic aneurysm and dissection (AAD) is a life-threatening medical condition associated with
high morbidity and mortality rates. Important mechanisms underlying AAD are the …

JAK2V617F mutation drives vascular resident macrophages toward a pathogenic phenotype and promotes dissecting aortic aneurysm

R Al-Rifai, M Vandestienne, JR Lavillegrand… - nature …, 2022 - nature.com
Abstract JAK2V617F mutation is associated with an increased risk for athero-thrombotic
cardiovascular disease, but its role in aortic disease development and complications …

Perspective of SGLT2i in the treatment of abdominal aortic aneurysms

Z Jin, H Deng, S Xiong, L Gao - Journal of Cardiovascular …, 2023 - journals.lww.com
The incidence of abdominal aortic aneurysm (AAA) in the elderly is increasing year by year
with high mortality. Current treatment is mainly through surgery or endovascular intervention …

Exogenous l-fucose attenuates neuroinflammation induced by lipopolysaccharide

X Xu, T Fukuda, J Takai, S Morii, Y Sun, J Liu… - Journal of Biological …, 2024 - ASBMB
α1, 6-Fucosyltransferase (Fut8) catalyzes the transfer of fucose to the innermost GlcNAc
residue of N-glycan to form core fucosylation. Our previous studies showed that …

Extravascular administration of IGF1R antagonists protects against aortic aneurysm in rodent and porcine models

Y Wei, H Jiang, F Li, C Chai, Y Xu, M Xing… - Science Translational …, 2024 - science.org
An abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease. We
identified plasma insulin-like growth factor 1 (IGF1) as an independent risk factor in patients …

Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice

Y Zhou, H Chai, Y Hu, R Liu, H Jiang, R Fan… - Biochemical and …, 2022 - Elsevier
In recent years, abdominal aortic aneurysm (AAA) lesions have become one of the important
diseases that threaten public health. Related studies have confirmed that the occurrence of …

Clinical value of serum miR-1-3p as a potential circulating biomarker for abdominal aortic aneurysm

J Jing, M Chang, S Jiang, T Wang, Q Sun… - Annals of …, 2023 - Taylor & Francis
Background Although abdominal aortic aneurysm (AAA) is associated with life-threatening
complications, there are still limited reliable biomarkers for diagnostic purpose. MicroRNAs …

Genetic deficiency of protein inhibitor of activated STAT3 suppresses experimental abdominal aortic aneurysms

W Fu, H Liu, P Wei, C Xia, Q Yu, K Tian, Y Li… - Frontiers in …, 2023 - frontiersin.org
Aim Signal transducer and activator of transcription (STAT) signaling is critical for the
pathogenesis of abdominal aortic aneurysms (AAAs). Though protein inhibitor of activated …

Identification of abdominal aortic aneurysm subtypes based on mechanosensitive genes

C Sheng, Q Zeng, W Huang, M Liao, P Yang - Plos one, 2024 - journals.plos.org
Background Rupture of abdominal aortic aneurysm (rAAA) is a fatal event in the elderly.
Elevated blood pressure and weakening of vessel wall strength are major risk factors for this …

Single-cell sequencing reveals the impact of endothelial cell PIEZO1 expression on thoracic aortic aneurysm

X Xiao, H Liu, J Wan, P Yang, Z Xu, S Wang… - Journal of Molecular and …, 2024 - Elsevier
Introduction Thoracic aortic aneurysm (TAA) is a severe vascular disease that threatens
human life, characterized by focal dilatation of the entire aortic wall, with a diameter 1.5 …