[HTML][HTML] Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis
S Murao, H Nakata, I Roberts, K Yamakawa - Critical Care, 2021 - Springer
Background Tranexamic acid (TXA) reduces surgical bleeding and reduces death from
bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures …
bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures …
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis
Objective To assess the effect of tranexamic acid on blood transfusion, thromboembolic
events, and mortality in surgical patients. Design Systematic review and meta-analysis. Data …
events, and mortality in surgical patients. Design Systematic review and meta-analysis. Data …
Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis
PL McCormack - Drugs, 2012 - Springer
Tranexamic acid, a synthetic derivative of the amino acid lysine, is an antifibrinolytic agent
that acts by binding to plasminogen and blocking the interaction of plasmin (ogen) with …
that acts by binding to plasminogen and blocking the interaction of plasmin (ogen) with …
Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology
SA Kozek-Langenecker, A Afshari… - European Journal of …, 2013 - journals.lww.com
The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …
identification by anamesis and laboratory testing of those patients for whom the …
Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery
JR Brown, NJO Birkmeyer, GT O'Connor - Circulation, 2007 - Am Heart Assoc
Background—Since the 1980s, antifibrinolytic therapies have assisted surgical teams in
reducing the amount of blood loss. To date, however, serious questions remain regarding …
reducing the amount of blood loss. To date, however, serious questions remain regarding …
Pharmacokinetics of tranexamic acid during cardiopulmonary bypass
NP Dowd, JM Karski, DC Cheng, JA Carroll… - The Journal of the …, 2002 - pubs.asahq.org
Background Tranexamic acid (TA) reduces blood loss and blood transfusion during heart
surgery with cardiopulmonary bypass (CPB). TA dosing has been empiric because only …
surgery with cardiopulmonary bypass (CPB). TA dosing has been empiric because only …
Exposure–response relationship of tranexamic acid in cardiac surgery: a model-based meta-analysis
PJ Zufferey, J Lanoiselee, B Graouch, B Vieille… - …, 2021 - pubs.asahq.org
Background It is unclear whether high-dose regimens of tranexamic acid in cardiac surgery
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
(total dose, 80 to 100 mg/kg) confer a clinical advantage over low-dose regimens (total dose …
Mechanisms and attenuation of hemostatic activation during extracorporeal circulation
GJ Despotis, MS Avidan, CW Hogue Jr - The Annals of thoracic surgery, 2001 - Elsevier
Patients undergoing cardiac surgery with cardiopulmonary bypass are at risk for excessive
microvascular bleeding, which often leads to transfusion of allogeneic blood and blood …
microvascular bleeding, which often leads to transfusion of allogeneic blood and blood …
Perioperative systemic haemostatic agents
AM Mahdy, NR Webster - British journal of anaesthesia, 2004 - academic.oup.com
Skilful surgery combined with blood-saving methods and careful management of blood
coagulation will all help reduce unnecessary blood loss and transfusion requirements …
coagulation will all help reduce unnecessary blood loss and transfusion requirements …
Hyperfibrinolysis elicited via thromboelastography predicts mortality in trauma
BACKGROUND: The acute coagulopathy of trauma has been identified as a critical
determinant of outcomes. Antifibrinolytic agents have recently been demonstrated to …
determinant of outcomes. Antifibrinolytic agents have recently been demonstrated to …