[HTML][HTML] L-carnitine and acylcarnitines: mitochondrial biomarkers for precision medicine

MR McCann, MV George De la Rosa, GR Rosania… - Metabolites, 2021 - mdpi.com
Biomarker discovery and implementation are at the forefront of the precision medicine
movement. Modern advances in the field of metabolomics afford the opportunity to readily …

Celastrol in cancer therapy: Recent developments, challenges and prospects

HY Lim, PS Ong, L Wang, A Goel, L Ding, ALA Wong… - Cancer Letters, 2021 - Elsevier
Cancer is one of the world's biggest healthcare burdens and despite the current
advancements made in treatment plans, the outcomes for oncology patients have yet to …

Bioactive glass: A multifunctional delivery system

S Gupta, S Majumdar, S Krishnamurthy - Journal of Controlled Release, 2021 - Elsevier
Bioactive glasses (BAGs) were invented five decades ago and have been widely used
clinically in orthopedic and stomatology. However, in the past two decades, BAGs have …

Machine learning techniques and drug design

JC Gertrudes, VG Maltarollo, RA Silva… - Current medicinal …, 2012 - ingentaconnect.com
The interest in the application of machine learning techniques (MLT) as drug design tools is
growing in the last decades. The reason for this is related to the fact that the drug design is …

[HTML][HTML] A comprehensive review on pharmacological, toxicity, and pharmacokinetic properties of phillygenin: Current landscape and future perspectives

C Wang, R Wu, S Zhang, L Gong, K Fu, C Yao… - Biomedicine & …, 2023 - Elsevier
Forsythiae Fructus is a traditional Chinese medicine frequently in clinics. It is extensive in the
treatment of various inflammation-related diseases and is renowned as' the holy medicine of …

[HTML][HTML] Alpinetin: a review of its pharmacology and pharmacokinetics

G Zhao, Y Tong, F Luan, W Zhu, C Zhan… - Frontiers in …, 2022 - frontiersin.org
Flavonoids isolated from medicinal herbs have been utilized as valuable health-care agents
due to their virous biological applications. Alpinetin is a natural flavonoid that emerges in …

Pharmacogenomics: challenges and opportunities

DM Roden, RB Altman, NL Benowitz… - Annals of internal …, 2006 - acpjournals.org
The outcome of drug therapy is often unpredictable, ranging from beneficial effects to lack of
efficacy to serious adverse effects. Variations in single genes are 1 well-recognized cause of …

An integrated transfer learning and multitask learning approach for pharmacokinetic parameter prediction

Z Ye, Y Yang, X Li, D Cao, D Ouyang - Molecular pharmaceutics, 2018 - ACS Publications
Background: Pharmacokinetic evaluation is one of the key processes in drug discovery and
development. However, current absorption, distribution, metabolism, and excretion …

SuperCYPsPred—a web server for the prediction of cytochrome activity

P Banerjee, M Dunkel, E Kemmler… - Nucleic acids …, 2020 - academic.oup.com
Abstract Cytochrome P450 enzymes (CYPs)-mediated drug metabolism influences drug
pharmacokinetics and results in adverse outcomes in patients through drug–drug …

Pharmacokinetic Assessment of Rottlerin from Mallotus philippensis Using a Highly Sensitive Liquid Chromatography–Tandem Mass Spectrometry-Based …

D Manhas, A Gour, N Bhardwaj, DK Sharma… - ACS …, 2021 - ACS Publications
Rottlerin is a key bioactive phytoconstituent present in the pericarp of Mallotus philippensis.
It shows promising multifaceted pharmacological actions against cancer. However, there is …