[HTML][HTML] The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy
C Grinán-Ferré, A Bellver-Sanchis, V Izquierdo… - Ageing Research …, 2021 - Elsevier
While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …
CpG islands and the regulation of transcription
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
significantly from the average genomic pattern by being GC-rich, CpG-rich, and …
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Polycomb group proteins are transcriptional repressors that are essential for normal gene
regulation during development. Recent studies suggest that Polycomb repressive …
regulation during development. Recent studies suggest that Polycomb repressive …
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness
T Pachano, V Sánchez-Gaya, T Ealo, M Mariner-Faulí… - Nature …, 2021 - nature.com
CpG islands (CGIs) represent a widespread feature of vertebrate genomes, being
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …
associated with~ 70% of all gene promoters. CGIs control transcription initiation by …
[HTML][HTML] KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …
act as polycomb response elements (PREs) and are recognized by the polycomb silencing …
Enhancer DNA methylation: implications for gene regulation
A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …
[HTML][HTML] Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation
Summary Polycomb repressive complex 1 (PRC1) catalyzes lysine 119 monoubiquitylation
on H2A (H2AK119ub1) and regulates pluripotency in embryonic stem cells (ESCs) …
on H2A (H2AK119ub1) and regulates pluripotency in embryonic stem cells (ESCs) …
Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed
Histone deacetylase inhibitors (HDACis) have now emerged as a powerful new class of
small-molecule therapeutics acting through the regulation of the acetylation states of histone …
small-molecule therapeutics acting through the regulation of the acetylation states of histone …
Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant
S Denissov, H Hofemeister, H Marks, A Kranz… - …, 2014 - journals.biologists.com
Trimethylation of histone H3 lysine 4 (H3K4me3) at the promoters of actively transcribed
genes is a universal epigenetic mark and a key product of Trithorax group action. Here, we …
genes is a universal epigenetic mark and a key product of Trithorax group action. Here, we …
DNA methylation: TET proteins—guardians of CpG islands?
K Williams, J Christensen, K Helin - EMBO reports, 2012 - embopress.org
DNA methylation is involved in key cellular processes, including X‐chromosome
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …
inactivation, imprinting and transcriptional silencing of specific genes and repetitive …