Genetic impacts on DNA methylation: research findings and future perspectives
S Villicaña, JT Bell - Genome biology, 2021 - Springer
Multiple recent studies highlight that genetic variants can have strong impacts on a
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
significant proportion of the human DNA methylome. Methylation quantitative trait loci, or …
Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
Systematic identification of genetic influences on methylation across the human life course
Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
Given the tissue-specific nature of epigenetic processes, the assessment of disease-relevant
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
tissue is an important consideration for epigenome-wide association studies (EWAS). Little …
Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases
YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …
throughput technologies enable omics studies interrogating thousands to millions of makers …
Genetic contributions to autism spectrum disorder
A Havdahl, M Niarchou, A Starnawska… - Psychological …, 2021 - cambridge.org
Autism spectrum disorder (autism) is a heterogeneous group of neurodevelopmental
conditions characterized by early childhood-onset impairments in communication and social …
conditions characterized by early childhood-onset impairments in communication and social …
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
DNA methylation has become increasingly recognized in the etiology of psychiatric
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
disorders. Because brain tissue is not accessible in living humans, epigenetic studies are …
Identification of 55,000 replicated DNA methylation QTL
DNA methylation plays an important role in the regulation of transcription. Genetic control of
DNA methylation is a potential candidate for explaining the many identified SNP …
DNA methylation is a potential candidate for explaining the many identified SNP …
Accounting for population stratification in DNA methylation studies
ABSTRACT DNA methylation is an important epigenetic mechanism that has been linked to
complex diseases and is of great interest to researchers as a potential link between …
complex diseases and is of great interest to researchers as a potential link between …
Oxytocin receptor genetic and epigenetic variations: association with child abuse and adult psychiatric symptoms
EL Smearman, LM Almli, KN Conneely… - Child …, 2016 - Wiley Online Library
Childhood abuse can alter biological systems and increase risk for adult psychopathology.
Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are …
Epigenetic mechanisms, alterations in DNA structure that regulate the gene expression, are …