DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …

Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells
(PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are …

DNA methylation is one of the best-characterized epigenetic modifications and has been
implicated in numerous biological processes, including transposable element silencing …

Spermatogenesis is a fundamental process in male reproductive biology and depends on
precise balance between self-renewal and differentiation of male germ cells. However, the …

Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

Spatially ordered embryo-like structures self-assembled from blastocyst-derived stem cells
can be generated to mimic embryogenesis in vitro. However, the assembly system and …

The production of spermatozoa relies on a pool of spermatogonial stem cells (SSCs), formed
in infancy from the differentiation of their precursor cells, the gonocytes. Throughout adult …

Mutations in ASPM (abnormal spindle-like microcephaly associated) cause primary
microcephaly in humans, a disorder characterized by a major reduction in brain size in the …

Interferon-induced transmembrane (IFITM) genes are transcribed in most tissues and are
with the exception of IFITM5 interferon inducible. They are involved in early development …