DNA damage is correlated with and may drive the ageing process. Neurons in the brain are
postmitotic and are excluded from many forms of DNA repair; therefore, neurons are …

Ageing, a leading cause of the decline/deficits in human learning, memory, and cognitive
abilities, is a major risk factor for age-associated neurodegenerative disorders such as …

Background Several recent studies reported aging effects on DNA methylation levels of
individual CpG dinucleotides. But it is not yet known whether aging-related consensus …

DNA methylation is an important epigenetic regulator of gene expression. Recent studies
have revealed widespread associations between genetic variation and methylation levels …

Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Amyotrophic lateral sclerosis (ALS) is a terminal disease involving the progressive
degeneration of motor neurons within the motor cortex, brainstem and spinal cord. Most …

Plants have evolved several strategies, including regulation of genes through epigenetic
modifications, to cope with environmental stresses. DNA methylation is dynamically …

The earliest stages of Huntington disease are marked by changes in gene expression that
are caused in an indirect and poorly understood manner by polyglutamine expansions in the …

A decline in skeletal muscle mass and function with aging is well recognized, but remains
poorly characterized at the molecular level. Here, we report for the first time a genome‐wide …

5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine.
While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is …