Epigenetic modifications work in concert with genetic mechanisms to regulate transcriptional
activity in normal tissues and are often dysregulated in disease. Although they are …

Epigenetic, along with genetic mechanisms, is essential for natural evolution and
maintenance of specific patterns of gene expression in mammalians. Global epigenetic …

Chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) are associated with
hepatic fibrosis and development of hepatocellular carcinoma (HCC). There are differences …

Aim: DNA methylation programs gene expression and is involved in numerous biological
processes. Accumulating evidence supports transgenerational inheritance of DNA …

An unstable genome is a hallmark of many cancers. It is unclear, however, whether some
mutagenic features driving somatic alterations in cancer are encoded in the genome …

Genetic instability is one of the principal hallmarks and causative factors in cancer. Human
transposable elements (TE) have been reported to cause human diseases, including …

Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans.
The molecular mechanisms leading to the development of HCC are extremely complicated …

Altered DNA methylation is ubiquitous in human cancers and specific methylation changes
are often correlated with clinical features. DNA methylation biomarkers, which use those …

Hepatocellular carcinoma (HCC) incidence has increased in the US and also has one of the
fastest growing death rates of any cancer. The purpose of the current study was to discover …

Abstract Hypoxia-inducible factor 1 (HIF-1) emerges as a crucial player in tumor
progression. However, its role in hepatocellular carcinoma (HCC), especially its relation with …