Diabetes mellitus, which affects more than 463 million people globally, is caused by the
autoimmune ablation or functional loss of insulin-producing β-cells, and prevalence is …

The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …

Diabetes is one of the most socially challenging health concerns. Even though islet
transplantation has shown promise for insulin-dependent diabetes, there is still no effective …

With rising global demand for food proteins and significant environmental impact associated
with conventional animal agriculture, it is important to develop sustainable alternatives to …

Almost 50 years ago, scientists developed the bi-hormonal abnormality hypothesis, stating
that diabetes is not caused merely by the impaired insulin signaling. Instead, the presence of …

Type 2 diabetes, characterized by dysfunction of pancreatic β-cells and insulin resistance in
peripheral organs, accounts for more than 90% of all diabetes. Despite current …

In insulin-dependent diabetes, the islet β cells do not produce enough insulin and the
patients must receive exogenous insulin to control blood sugar. However, there are still …

The endodermal germ layer gives rise to respiratory epithelium, hepatocytes, pancreatic
cells and intestinal lineages, among other cell types. These lineages can be differentiated …

Diabetes mellitus (DM) is a group of metabolic disorders characterized by high blood
glucose levels due to insufficient insulin secretion, insulin action, or both. The present-day …

For the production and bio-banking of differentiated derivatives from human pluripotent stem
cells (hPSCs) in large quantities for drug screening and cellular therapies, well-defined and …