The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

The iron-and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …

Intracranial germ cell tumours (IGCTs) are a group of rare heterogeneous brain tumours that
are clinically and histologically similar to the more common gonadal GCTs. IGCTs show …

Appropriate regulation of B cell differentiation into plasma cells is essential for humoral
immunity while preventing antibody-mediated autoimmunity; however, the underlying …

Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir
responsible for relapse in patients, years after curative surgery and adjuvant therapy. We …

Hypoxia is a hallmark of the tumor microenvironment and contributes to tumor malignant
phenotypes. Hypoxia-inducible factor (HIF) is a master regulator of intratumoral hypoxia and …

Vitamin C is an antioxidant that maintains the activity of iron and α‐ketoglutarate‐dependent
dioxygenases. Despite these enzymes being implicated in a wide range of biological …

Recent studies have revealed that chromatin remodeling, caused by DNA methylation and
histone modifications such as acetylation, methylation, and phosphorylation, plays a pivotal …

Glioma is regarded as an aggressive lethal primary brain tumor. Jumonji domain containing
1C (JMJD1C) is a H3K9 demethylase which participates in the progression of various …

Fatty acid and triglyceride synthesis increases greatly in response to feeding and insulin.
This lipogenic induction involves coordinate transcriptional activation of various enzymes in …