The dramatic re-organization of the cancer cell nucleus creates telltale morphological
features critical for pathological staging of tumors. In addition, the changes to the mutational …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Epigenetics involves a series of mechanisms that entail histone and DNA covalent
modifications and non-coding RNAs, and that collectively contribute to programing cell …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Epigenetics has attracted considerable attention with respect to its potential value in many
areas of agricultural production, particularly under conditions where the environment can be …

Two major functions of the epigenome are to regulate gene expression and to suppress
transposons. It is unclear how these functions are balanced during physiological challenges …

Over the past decade, the field of molecular biology has rapidly incorporated epigenetic
studies to evaluate organism–environment interactions that can result in chronic effects …

We hypothesized that the highly controlled pattern of gene expression that is essential for
liver regeneration is encoded by an epigenetic code set in quiescent hepatocytes. Here we …

Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …

All animals have evolved solutions to manage their genomes, enabling the efficient
organization of meters of DNA strands in the nucleus and allowing for nuanced regulation of …