Since the original identification of the T helper 17 (Th17) subset in 2005, it has become
evident that these cells do not only contribute to host defence against pathogens, such as …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

Mammalian neocortical neurons span one of the most diverse cell type spectra of any tissue.
Cortical neurons are born during embryonic development, and their maturation extends into …

Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …

Background DNA methylation at promoters is largely correlated with inhibition of gene
expression. However, the role of DNA methylation at enhancers is not fully understood …

DNA methylation in the form of 5-methylcytosine (5mC) is a key epigenetic regulator in
mammals, and the dynamic balance between methylation and demethylation impacts …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Evidence from both human and animal studies has shown that the prenatal and early
postnatal environments influence susceptibility to chronic disease in later life and suggests …

Gene expression in cells is determined by the epigenetic state of chromatin. Therefore, the
study of epigenetic changes is very important to understand the regulatory mechanism of …

Physical exercise represents one of the strongest physiological stimuli capable to induce
functional and structural modifications in all biological systems. Indeed, beside the …