Early transient developmental exposure to an endocrine active compound, diethylstilbestrol
(DES), a synthetic estrogen, causes late-stage effects in the reproductive tract of adult mice …

Solid tumors are characterized by a plethora of epigenetic changes. In particular, patterns
methylation of cytosines at the 5-position (5mC) in the context of CpGs are frequently altered …

We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs
discovered that the activity of glycogen phosphorylase is regulated by reversible protein …

Epigenetics controls the expression of genes and is responsible for cellular phenotypes. The
fundamental basis of these mechanisms involves in part the post-translational modifications …

Aims: The naive or primitive states of stem cells (SCs) residing in specific niches are
unstable and difficult to preserve in vitro. Vitamin C (VitC), in addition to suppressing oxygen …

In mammals, DNA methylation is a crucial epigenetic modification with key functions during
development. Cellular processes that are regulated by DNA methylation comprise X …

The long-term effects of developmental alcohol and stress exposure are well documented in
both humans and non-human animal models. Damage to the brain and attendant life-long …

Purpose. SOST gene is one of the key factors in regulating bone absorption. Although there
are reports showing diverse transcription factors, epigenetic modification could be …

Patients suffering from psychiatric disorders have a life span burden, which represents an
enormous human, family, social, and economical cost. Several concepts have revolutionized …

Epigenetic modifications, including DNA methylation, covalent histone modifications, and
small noncoding RNAs, play a key role in regulating the gene expression. This regulatory …