Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

J Zhen, Z Zhou, M He, HX Han, EH Lv… - Frontiers in …, 2023 - frontiersin.org
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide.
Researchers have found that the occurrence and development of CVDs are closely related …

The role of the gut microbiota in health and cardiovascular diseases

L Wang, S Wang, Q Zhang, C He, C Fu, Q Wei - Molecular biomedicine, 2022 - Springer
The gut microbiota is critical to human health, such as digesting nutrients, forming the
intestinal epithelial barrier, regulating immune function, producing vitamins and hormones …

Homeostasis in the gut microbiota in chronic kidney disease

S Bhargava, E Merckelbach, H Noels, A Vohra… - Toxins, 2022 - mdpi.com
The gut microbiota consists of trillions of microorganisms, fulfilling important roles in
metabolism, nutritional intake, physiology and maturation of the immune system, but also …

Gut microbes in cerebrovascular diseases: gut flora imbalance, potential impact mechanisms and promising treatment strategies

X Zou, L Wang, L Xiao, S Wang, L Zhang - Frontiers in immunology, 2022 - frontiersin.org
The high morbidity, mortality, and disability rates associated with cerebrovascular disease
(CeVD) pose a severe danger to human health. Gut bacteria significantly affect the onset …

Microbiota-mediated metabolic perturbations in the gut and brain of mice after microplastic exposure

SH Lee, WY Lin, TJ Cheng - Chemosphere, 2024 - Elsevier
Microplastics (MPs), emerging environmental toxicants, have drawn attention because of
their wide distribution in the environment. Exposure to MPs induces gut microbiota …

Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical …

MS Mihuta, C Paul, A Borlea, CM Roi… - Frontiers in …, 2023 - frontiersin.org
Introduction Childhood obesity leads to early subclinical atherosclerosis and arterial
stiffness. Studying biomarkers like trimethylamine N-oxide (TMAO), linked to cardio …

Inadequate choline intake in pregnant women in Germany

M Roeren, A Kordowski, C Sina, M Smollich - Nutrients, 2022 - mdpi.com
Choline is an essential nutrient that is involved in various developmental processes during
pregnancy. While the general adequate choline intake (AI) for adults has been set at 400 …

[HTML][HTML] Assessment of dietary choline intake, contributing food items, and associations with one-carbon and lipid metabolites in middle-aged and elderly adults: the …

A Van Parys, MS Brække, T Karlsson, KJ Vinknes… - The Journal of …, 2022 - Elsevier
Background Choline is an essential nutrient for humans and is involved in various
physiologic functions. Through its metabolite betaine, it is closely connected to the one …

Trimethylamine-N-oxide sensitizes chondrocytes to mechanical loading through the upregulation of Piezo1

H Zhuang, X Ren, Y Zhang, F Jiang, P Zhou - Food and Chemical …, 2023 - Elsevier
Background Mechanical strain plays a crucial role in chondrocyte apoptosis and
osteoarthritis (OA) disease progression through Piezo1. Trimethylamine-N-oxide (TMAO) is …