The prokaryote-derived CRISPR–Cas genome editing technology has altered plant
molecular biology beyond all expectations. Characterized by robustness and high target …

Enhanced agricultural production through innovative breeding technology is urgently
needed to increase access to nutritious foods worldwide. Recent advances in CRISPR/Cas …

Genome editing (GE) has revolutionized biological research through the new ability to
precisely edit the genomes of living organisms. In recent years, various GE tools have been …

Plant intra-individual and inter-individual variation can be determined by the epigenome, a
set of covalent modifications of DNA and chromatin that can alter genome structure and …

The application of clustered regularly interspaced short palindromic repeats (CRISPR) for
genetic manipulation has revolutionized life science over the past few years. CRISPR was …

Traditionally, generation of new plants with improved or desirable features has relied on
laborious and time-consuming breeding techniques. Genome-editing technologies have led …

Epigenetic modifications in DNA bases and histone proteins play important roles in the
regulation of gene expression and genome stability. Chemical modification of DNA base …

Understanding genomic functions requires site-specific manipulation of loci via efficient
protein effector targeting systems. However, few approaches for targeted manipulation of the …

DNA methylation is an epigenetic mark that regulates multiple processes, such as gene
expression and genome stability. Mutants and pharmacological treatments have been …

DNA methylation generally functions as a repressive transcriptional signal, but it is also
known to activate gene expression. In either case, the downstream factors remain largely …