The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Cell culture is an important and necessary process in drug discovery, cancer research, as
well as stem cell study. Most cells are currently cultured using two-dimensional (2D) …

Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …

It is becoming recognized that screening of oncology drugs on a platform using two-
dimensionally (2D)-cultured cell lines is unable to precisely select clinically active drugs; …

New cancer drug approval rates are≤ 5% despite significant investments in cancer
research, drug discovery and development. One strategy to improve the rate of success of …

Background Cancer cell resistance to therapeutics can result from acquired or de novo-
mediated factors. Here, we have utilised advanced breast cancer cell culture models to …

This review covers several aspects of microfluidic devices used for culturing and monitoring
of both adherent and non-adherent cells, including a multitude of applications. A comparison …

Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …

For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …