Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

Modern neuropathology serves a key function in the multidisciplinary management of brain
tumor patients. Owing to the recent advancements in molecular neurooncology, the …

Caspase-8 is an apical caspase which initiates programmed cell death following death
receptor ligation. This central role in apoptosis has prompted significant clinical interest in …

Survival rates of pediatric brain tumor patients have significantly improved over the years
due to developments in diagnostic techniques, neurosurgery, chemotherapy, radiotherapy …

DNA methylation is an epigenetic phenomenon known to play an increasingly important role
in the etiology of cancer. Changes in DNA methylation patterns particularly in the promoter …

Downregulation of E‐cadherin in solid tumors with regional migration and systematic
metastasis is well recognized. In view of its significance in tumorigenesis and solid cancer …

Therapies targeting cancer metastasis are challenging owing to the complexity of the
metastatic process and the high number of effectors involved. Although tumour hypoxia has …

Wound healing in the skin is a complex physiological process that is a product of a cell state
transition from homeostasis to repair. Mechanical cues are increasingly being recognized as …

Abstract Development of resistance to TRAIL-induced toxicity is one of the strategies used
from tumor cells to escape destruction from the immune system. This process may occur …