DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …

DNA methylation is frequently described as a'silencing'epigenetic mark, and indeed this
function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved …

DNA methylation is a chemical modification of cytosine bases that is pivotal for gene
regulation, cellular specification and cancer development. Here, we describe an R package …

Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …

Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This
may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known …

Background Chronic psychological stress is associated with accelerated aging and
increased risk for aging-related diseases, but the underlying molecular mechanisms are …

The activity of the glucocorticoid receptor (GR), a nuclear receptor transcription factor
belonging to subclass 3C of the steroid/thyroid hormone receptor superfamily, is typically …

Although DNA methylation is commonly invoked as a mechanism for transcriptional
repression, the extent to which it actively silences transcription factor (TF) occupancy sites in …

DNA methylation involves the addition of a methyl group to the fifth carbon of the pyrimidine
cytosine ring (5-methylcytosine, 5mC). 5mC is widespread in vertebrate genomes where it is …

Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …