Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide.
A large proportion of patients with HCC are diagnosed at advanced stages and are only …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Abstract Over 90 years ago, Otto Warburg's seminal discovery of aerobic glycolysis
established metabolic reprogramming as one of the first distinguishing characteristics of …

Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …