The epigenetic basis of cellular heterogeneity
Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …
substantial heterogeneity in expression levels among morphologically indistinguishable …
Third‐generation sequencing of epigenetic DNA
The discovery of epigenetic bases has revolutionised the understanding of disease and
development. Among the most studied epigenetic marks are cytosines covalently modified at …
development. Among the most studied epigenetic marks are cytosines covalently modified at …
[HTML][HTML] Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
mark with the capacity to silence promoters. Epigenome engineering techniques enable …
[HTML][HTML] TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis
Mutations in the epigenetic modifier TET2 are frequent in myeloid malignancies and clonal
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of undetermined …
GRAND: a database of gene regulatory network models across human conditions
M Ben Guebila, CM Lopes-Ramos… - Nucleic Acids …, 2022 - academic.oup.com
Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …
to perturbation. Regulatory processes are controlled by complex networks of interacting …
[HTML][HTML] Cancer epigenetics: from laboratory studies and clinical trials to precision medicine
X Yu, H Zhao, R Wang, Y Chen, X Ouyang, W Li… - Cell Death …, 2024 - nature.com
Epigenetic dysregulation is a common feature of a myriad of human diseases, particularly
cancer. Defining the epigenetic defects associated with malignant tumors has become a …
cancer. Defining the epigenetic defects associated with malignant tumors has become a …
[HTML][HTML] Integrated analysis of whole genome and epigenome data using machine learning technology: toward the establishment of precision oncology
With the completion of the International Human Genome Project, we have entered what is
known as the post-genome era, and efforts to apply genomic information to medicine have …
known as the post-genome era, and efforts to apply genomic information to medicine have …
Long-read whole-genome methylation patterning using enzymatic base conversion and nanopore sequencing
Y Sakamoto, S Zaha, S Nagasawa… - Nucleic Acids …, 2021 - academic.oup.com
Long-read whole-genome sequencing analysis of DNA methylation would provide useful
information on the chromosomal context of gene expression regulation. Here we describe …
information on the chromosomal context of gene expression regulation. Here we describe …
Metabolism navigates neural cell fate in development, aging and neurodegeneration
An uninterrupted energy supply is critical for the optimal functioning of all our organs, and in
this regard the human brain is particularly energy dependent. The study of energy metabolic …
this regard the human brain is particularly energy dependent. The study of energy metabolic …
EpiTEAmDNA: Sequence feature representation via transfer learning and ensemble learning for identifying multiple DNA epigenetic modification types across species
Methylation is a major DNA epigenetic modification for regulating the biological processes
without altering the DNA sequence, and multiple types of DNA methylations have been …
without altering the DNA sequence, and multiple types of DNA methylations have been …