The pathogenesis of rheumatoid arthritis
S Alivernini, GS Firestein, IB McInnes - Immunity, 2022 - cell.com
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …
Mechanisms of joint destruction in rheumatoid arthritis—immune cell–fibroblast–bone interactions
N Komatsu, H Takayanagi - Nature Reviews Rheumatology, 2022 - nature.com
Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
Fibroblasts as immune regulators in infection, inflammation and cancer
In chronic infection, inflammation and cancer, the tissue microenvironment controls how
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
local immune cells behave, with tissue-resident fibroblasts emerging as a key cell type in …
[HTML][HTML] Cytokine networks in the pathogenesis of rheumatoid arthritis
N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …
inflammation causing progressive joint damage that can lead to lifelong disability. The …
Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes
G Nygaard, GS Firestein - Nature Reviews Rheumatology, 2020 - nature.com
Rheumatoid arthritis (RA) is a chronic immune-mediated disease that primarily affects the
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
synovium of diarthrodial joints. During the course of RA, the synovium transforms into a …
[HTML][HTML] Promising therapeutic targets for treatment of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …
Rheumatoid arthritis: advances in treatment strategies
P Prasad, S Verma, Surbhi, NK Ganguly… - Molecular and cellular …, 2023 - Springer
Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to
heightened autoimmune response at the articular sites. Worldwide annual incidence and …
heightened autoimmune response at the articular sites. Worldwide annual incidence and …
Origin and functional heterogeneity of fibroblasts
VS LeBleu, EG Neilson - The FASEB Journal, 2020 - Wiley Online Library
The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for
basic research. But where do they come from, are all fibroblasts the same, and how do they …
basic research. But where do they come from, are all fibroblasts the same, and how do they …
The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis
N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …
[HTML][HTML] Critical role of synovial tissue–resident macrophage and fibroblast subsets in the persistence of joint inflammation
Rheumatoid arthritis (RA) is a chronic prototypic immune-mediated inflammatory disease
which is characterized by persistent synovial inflammation, leading to progressive joint …
which is characterized by persistent synovial inflammation, leading to progressive joint …