Iron and copper as virulence modulators in human fungal pathogens
Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …
between acquiring essential metals and defending against metal toxicity. Iron and copper …
The high osmolarity glycerol (HOG) pathway in fungi†
H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …
Mechanisms of infection by the human fungal pathogen Cryptococcus neoformans
Brain infection by the fungus Cryptococcus neoformans results in inflammation of the
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …
The Cryptococcus neoformans transcriptome at the site of human meningitis
Y Chen, DL Toffaletti, JL Tenor, AP Litvintseva, C Fang… - MBio, 2014 - Am Soc Microbiol
Cryptococcus neoformans is the leading cause of fungal meningitis worldwide. Previous
studies have characterized the cryptococcal transcriptome under various stress conditions …
studies have characterized the cryptococcal transcriptome under various stress conditions …
The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans
B Cadieux, T Lian, G Hu, J Wang… - The Journal of …, 2013 - academic.oup.com
Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …
The copper regulon of the human fungal pathogen Cryptococcus neoformans H99
Cryptococcus neoformans is a human fungal pathogen that is the causative agent of
cryptococcosis and fatal meningitis in immuno‐compromised hosts. Recent studies suggest …
cryptococcosis and fatal meningitis in immuno‐compromised hosts. Recent studies suggest …
The tools for virulence of Cryptococcus neoformans
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
each year. It is believed that most humans are infected with C. neoformans, possibly in a …
Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence
J Kronstad, S Saikia, ED Nielson, M Kretschmer… - Eukaryotic …, 2012 - Am Soc Microbiol
The basidiomycete fungus Cryptococcus neoformans infects humans via inhalation of
desiccated yeast cells or spores from the environment. In the absence of effective immune …
desiccated yeast cells or spores from the environment. In the absence of effective immune …
Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies
Life-threatening invasive fungal infections are becoming increasingly common, at least in
part due to the prevalence of medical interventions resulting in immunosuppression …
part due to the prevalence of medical interventions resulting in immunosuppression …
Mechanisms of cryptococcal virulence and persistence
MA Olszewski, Y Zhang, GB Huffnagle - Future microbiology, 2010 - Future Medicine
Cryptococcus neoformans is an environmental yeast that is a leading cause of fatal mycosis
in AIDS patients and a major cause of meningoencephalitis and CNS-related mortality …
in AIDS patients and a major cause of meningoencephalitis and CNS-related mortality …