Iron and copper as virulence modulators in human fungal pathogens

C Ding, RA Festa, TS Sun, ZY Wang - Molecular microbiology, 2014 - Wiley Online Library
Fungal pathogens have evolved sophisticated machinery to precisely balance the fine line
between acquiring essential metals and defending against metal toxicity. Iron and copper …

The high osmolarity glycerol (HOG) pathway in fungi

H Yaakoub, NS Sanchez, L Ongay-Larios… - Critical Reviews in …, 2022 - Taylor & Francis
While fungi are widely occupying nature, many species are responsible for devastating
mycosis in humans. Such niche diversity explains how quick fungal adaptation is necessary …

Mechanisms of infection by the human fungal pathogen Cryptococcus neoformans

W Sabiiti, RC May - Future microbiology, 2012 - Future Medicine
Brain infection by the fungus Cryptococcus neoformans results in inflammation of the
meninges and brain parenchyma, a condition known as meningoencephalitis. One million …

The Cryptococcus neoformans transcriptome at the site of human meningitis

Y Chen, DL Toffaletti, JL Tenor, AP Litvintseva, C Fang… - MBio, 2014 - Am Soc Microbiol
Cryptococcus neoformans is the leading cause of fungal meningitis worldwide. Previous
studies have characterized the cryptococcal transcriptome under various stress conditions …

The Mannoprotein Cig1 Supports Iron Acquisition From Heme and Virulence in the Pathogenic Fungus Cryptococcus neoformans

B Cadieux, T Lian, G Hu, J Wang… - The Journal of …, 2013 - academic.oup.com
Iron acquisition is critical for virulence of the human pathogenic fungus Cryptococcus
neoformans. The cryptococcal transcript for the extracellular mannoprotein Cig1 is highly …

The copper regulon of the human fungal pathogen Cryptococcus neoformans H99

C Ding, J Yin, EMM Tovar, DA Fitzpatrick… - Molecular …, 2011 - Wiley Online Library
Cryptococcus neoformans is a human fungal pathogen that is the causative agent of
cryptococcosis and fatal meningitis in immuno‐compromised hosts. Recent studies suggest …

The tools for virulence of Cryptococcus neoformans

C Coelho, AL Bocca, A Casadevall - Advances in applied microbiology, 2014 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

Adaptation of Cryptococcus neoformans to mammalian hosts: integrated regulation of metabolism and virulence

J Kronstad, S Saikia, ED Nielson, M Kretschmer… - Eukaryotic …, 2012 - Am Soc Microbiol
The basidiomycete fungus Cryptococcus neoformans infects humans via inhalation of
desiccated yeast cells or spores from the environment. In the absence of effective immune …

Opportunistic yeast pathogens: reservoirs, virulence mechanisms, and therapeutic strategies

EJ Polvi, X Li, TR O'Meara, MD Leach… - Cellular and Molecular …, 2015 - Springer
Life-threatening invasive fungal infections are becoming increasingly common, at least in
part due to the prevalence of medical interventions resulting in immunosuppression …

Mechanisms of cryptococcal virulence and persistence

MA Olszewski, Y Zhang, GB Huffnagle - Future microbiology, 2010 - Future Medicine
Cryptococcus neoformans is an environmental yeast that is a leading cause of fatal mycosis
in AIDS patients and a major cause of meningoencephalitis and CNS-related mortality …