Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the
relationship between gene activity and cell fates during development. Over the past few …

During mouse preimplantation embryo development, totipotent blastomeres generate the
first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm. In …

Spermatogenesis requires intricate interactions between the germline and somatic cells.
Within a given cross section of a seminiferous tubule, multiple germ and somatic cell types …

Adult mitotic tissues like the intestine, skin, and blood undergo constant turnover throughout
the life of an organism. Knowing the identity of the stem cell is crucial to understanding …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Abstract Development of the mammalian embryo begins with formation of the totipotent
zygote during fertilization. This initial cell is able to give rise to every embryonic tissue of the …

Abstract Background PolyA–RNAs have not been widely analyzed in human pre-
implantation embryos due to the scarcity of materials. In particular, circular RNA (circRNA), a …

Metabolic engineering aims to maximize the production of bio-economically important
substances (compounds, enzymes, or other proteins) through the optimization of the …

The epiblast is the source of all mammalian embryonic tissues and of pluripotent embryonic
stem cells. It differentiates alongside the primitive endoderm in a “salt and pepper” pattern …