COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects
DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …
Advancing cell therapy for neurodegenerative diseases
S Temple - Cell stem cell, 2023 - cell.com
Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …
A human three-dimensional neural-perivascular 'assembloid'promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …
2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are …
Shaping the brain vasculature in development and disease in the single-cell era
T Wälchli, J Bisschop, P Carmeliet, G Zadeh… - Nature Reviews …, 2023 - nature.com
The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …
Cytokines in CAR T cell–associated neurotoxicity
Chimeric antigen receptor (CAR) T cells provide new therapeutic options for patients with
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …
relapsed/refractory hematologic malignancies. However, neurotoxicity is a frequent, and …
Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
L Bejarano, A Kauzlaric, E Lamprou, J Lourenco… - Cancer cell, 2024 - cell.com
Brain metastasis (BrM) is a common malignancy, predominantly originating from lung,
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …
melanoma, and breast cancers. The vasculature is a key component of the BrM tumor …
Organ-specific endothelial cell differentiation and impact of microenvironmental cues on endothelial heterogeneity
L Gifre-Renom, M Daems, A Luttun… - International journal of …, 2022 - mdpi.com
Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …
specific functions of organs and tissues. Heterogeneity is already determined from …
Endothelial cell plasticity at the single-cell level
A Pasut, LM Becker, A Cuypers, P Carmeliet - Angiogenesis, 2021 - Springer
The vascular endothelium is characterized by a remarkable level of plasticity, which is the
driving force not only of physiological repair/remodeling of adult tissues but also of …
driving force not only of physiological repair/remodeling of adult tissues but also of …
Microvascular thrombosis: experimental and clinical implications
MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
A significant amount of clinical and research interest in thrombosis is focused on large
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
vessels (eg, stroke, myocardial infarction, deep venous thrombosis, etc.); however …
Organ-on-a-chip systems for vascular biology
Abstract Organ-on-a-chip (OOC) platforms involve the miniaturization of cell culture systems
and enable a variety of novel experimental approaches. These range from modeling the …
and enable a variety of novel experimental approaches. These range from modeling the …