[HTML][HTML] The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
[HTML][HTML] New GABA-targeting therapies for the treatment of seizures and epilepsy: I. Role of GABA as a modulator of seizure activity and recently approved …
E Perucca, M Bialer, HS White - CNS drugs, 2023 - Springer
Abstract γ-Aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter in the
mammalian brain and has been found to play an important role in the pathogenesis or the …
mammalian brain and has been found to play an important role in the pathogenesis or the …
[HTML][HTML] Tetraspanin assemblies in virus infection
L Florin, T Lang - Frontiers in immunology, 2018 - frontiersin.org
Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …
[HTML][HTML] Neonatal seizures—are we there yet?
Neonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in
early life and pose an immense challenge for clinicians. Improvements in neonatal care …
early life and pose an immense challenge for clinicians. Improvements in neonatal care …
The use of phenobarbital and other anti-seizure drugs in newborns
M El-Dib, JS Soul - Seminars in Fetal and Neonatal Medicine, 2017 - Elsevier
Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective
M Johne, K Römermann, P Hampel, B Gailus… - …, 2021 - Wiley Online Library
Objective Neonatal seizures are the most frequent type of neurological emergency in
newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital …
newborn infants, often being a consequence of prolonged perinatal asphyxia. Phenobarbital …
Acute symptomatic seizures in term neonates: Etiologies and treatments
JS Soul - Seminars in Fetal and Neonatal Medicine, 2018 - Elsevier
Acute symptomatic seizures caused by either diffuse or focal perinatal hypoxic–ischemic
insults and intracranial hemorrhage in term newborns make up the large majority of all …
insults and intracranial hemorrhage in term newborns make up the large majority of all …
[HTML][HTML] Symptomatic seizures in preterm newborns: a review on clinical features and prognosis
C Spagnoli, R Falsaperla, M Deolmi, G Corsello… - Italian journal of …, 2018 - Springer
Neonatal seizures are the most common neurological event in newborns, showing higher
prevalence in preterm than in full-term infants. In the majority of cases they represent acute …
prevalence in preterm than in full-term infants. In the majority of cases they represent acute …
[HTML][HTML] Perinatal brain injury and inflammation: lessons from experimental murine models
A Leavy, EM Jimenez Mateos - Cells, 2020 - mdpi.com
Perinatal brain injury or neonatal encephalopathy (NE) is a state of disturbed neurological
function in neonates, caused by a number of different aetiologies. The most prominent cause …
function in neonates, caused by a number of different aetiologies. The most prominent cause …
[HTML][HTML] Therapeutic drug monitoring is a feasible tool to personalize drug administration in neonates using new techniques: an overview on the pharmacokinetics and …
DU De Rose, S Cairoli, M Dionisi, A Santisi… - International journal of …, 2020 - mdpi.com
Therapeutic drug monitoring (TDM) should be adopted in all neonatal intensive care units
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …
(NICUs), where the most preterm and fragile babies are hospitalized and treated with many …