Cerebral aneurysms (CAs) occur in up to 5% of the population in the US, and up to 7% of all
strokes are caused by CA rupture. Little is known about the pathophysiology of cerebral …

Intracranial aneurysms (IA) are characterized by weakened cerebral vessel walls that may
lead to rupture and subarachnoid hemorrhage. The mechanisms behind their formation and …

Subarachnoid hemorrhage (SAH) is mainly attributable to the rupture of intracranial
aneurysms (IAs). Although the outcome of SAH is considerably poor in spite of the recent …

Maintenance of vascular integrity is required for embryogenesis and organ homeostasis.
However, the gene expression programs that stabilize blood vessels are poorly understood …

Cerebrovascular Diseases (CVD) comprise a wide spectrum of disorders, all sharing an
acquired or inherited alteration of the cerebral vasculature. CVD have been associated with …

Aneurysmal subarachnoid hemorrhage is caused by intracranial aneurysm (IA) rupture and
results in high rates of mortality and morbidity. Factors contributing to IA generation, growth …

The physiological and pathophysiological relevance of the angiotensin II type 1 (AT1) G
protein-coupled receptor no longer needs to be proven in the cardiovascular system. The …

The pathogenesis and natural history of intracranial aneurysm (IA) remains poorly
understood. To this end, animal models with induced cerebral vessel lesions mimicking …

The formation of cerebral aneurysms and their rupture propensity is of immediate clinical
importance. Current management includes observation with expectant management …

The human cerebrovascular system is responsible for maintaining neural function through
oxygenation, nutrient supply, filtration of toxins, and additional specialized tasks. While the …